MP21-04 SUCCESSFUL SPERM RETRIEVAL FOR MEN WITH Y CHROMOSOME AZFC MICRODELETION

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation I (MP21)1 Sep 2021MP21-04 SUCCESSFUL SPERM RETRIEVAL FOR MEN WITH Y CHROMOSOME AZFC MICRODELETION I-Shen Huang, Wei-Jen Chen, and William J Huang HuangI-Shen More articles by this author , ChenWei-Jen Chen HuangWilliam View All Author Informationhttps://doi.org/10.1097/JU.0000000000002006.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Among the genetic aberrations contributing male infertility, deletion AZFc region chromosome is a common cause spermatogenetic failure chances for successful surgical sperm extraction from azoospermic men with microdeletion are relatively good. Nevertheless, it still challenge procure sizeable proportion individuals microdeletion, even when meticulous measures employed. The objective study identify predictive factors retrieval in microdeletion. METHODS: 76 infertile were studied, each having at some time during 10-year period, as confirmed multiplex polymerase chain reaction (PCR) amplification STS (sequence tagged site). For patient, endocrine profile including serum follicle stimulating hormone (FSH), luteinizing (LH), total testosterone (TT), prolactin (PRL) estradiol (E2) was recorded, along intratesticular level (ITT), age testicular size. further analyzed determine key predictors retrieval. RESULTS: Of 56 classified non-obstructive azoospermia (NOA), 8 cryptozoospermia, 12 severe oligoasthenoteratozoospermia (OAT). azoospermia, 50 received microdissection TESE (mTESE), 37 those cases (74 %). A significantly lower FSH (P = 0.02) found patients whom could be successfully retrieved. On other hand, parameters such levels LH, TT, PRL, E2, volume not correlated recovery. area under receiving operating characteristic (ROC) curve (AUC) determined 0.721. Using an cut-off point 12.95 mIU/mL according Youden’s index, model predicting 51.4% sensitivity, 84.6% specificity, 90.5% positive value (PPV) 37.9% negative (NPV). CONCLUSIONS: Men exhibiting discernible spermatogenesis retrieved mTESE generally presented levels. Source Funding: nil © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e347-e347 Advertisement Copyright Permissions© Inc.MetricsAuthor Information Expand Loading ...